Robust renewal after extinction of remotely acquired Pavlovian conditioning
- Joseph W. Charles1,
- Samantha K. Moriarty1,
- Danielle I. Fournier1,
- Neil E. Winterbauer1,
- Emily A. Cooper2,3 and
- Travis P. Todd1
- 1Department of Psychological Science, University of Vermont, Burlington, Vermont 05405, USA
- 2Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, California 94720, USA
- 3Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
- Corresponding author: travis.todd{at}uvm.edu
Abstract
Extinguished responses are prone to renew outside the context where extinction occurred. Two experiments compared extinction and renewal following either a 1 day conditioning-to-extinction interval or a 27 day interval. Rats received tone-shock pairings in Context A, and extinction in Context B. Testing occurred in Context A (Experiment 1) or C (Experiment 2). Extinction occurred at a similar rate after both retention intervals. Robust renewal was also observed and was not affected by the conditioning-to-extinction retention interval. Results are discussed with respect to prior research on the timing of extinction, the neurobiology of recent and remote memory retrieval, and translational relevance.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.054103.125.
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Freely available online through the Learning & Memory Open Access option.
- Received February 26, 2025.
- Accepted April 23, 2025.
This article, published in Learning & Memory, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
