Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation
- Hongyu Zhao1,
- Arjan Blokland1,
- Jos Prickaerts2,
- Robbert Havekes3,
- Elroy L. Meijer3 and
- Pim R.A. Heckman1
- 1Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht 6229 ER, The Netherlands
- 2Peitho Translational, Maastricht 6229 ER, The Netherlands
- 3Neurobiology Expert Group, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9700 AB Groningen, The Netherlands
- Corresponding author: p.heckman{at}maastrichtuniversity.nl
Abstract
Insufficient sleep compromises the cAMP signaling pathway in the hippocampus, negatively impacting hippocampus-dependent memory. In the current study, we explored whether selective PDE4B or selective PDE4D inhibition can improve hippocampus-dependent spatial memory in the object location test (OLT) in mice after sleep deprivation (SD). The results demonstrated that SD impaired the OLT performance, and both A-33 and zatolmilast protected against the negative consequences of SD when administered at the start and middle of the SD period. These findings suggest that both PDE4B and PDE4D subfamilies contribute to the beneficial effect of PDE4 inhibition against SD-induced memory consolidation impairment.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.054101.125.
- Received February 18, 2025.
- Accepted May 15, 2025.
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