Inhibition of prefrontal glutamatergic neuron activity during the recovery period following chronic stress disrupts fear memory in male rats: potential role of the infralimbic cortex

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Figure 3.
Figure 3.

Freezing during spontaneous recovery and performance on the EPM. (A) Spontaneous recovery to tone was assessed 4–7 days after extinction. Group differences emerged when examining the sum of freezing time to all three tones. STR-R3-hM4Di rats froze significantly less and at chance levels compared to STR-R3-EGFP rats. This low freezing to tone indicated that STR-R3-hM4Di rats failed to show spontaneous recovery and as such, did not form a tone-foot shock association. No significant group differences were found in (B) time spent in open arms or (C) number of total arm entries. Data are reported as means ± SEM. (*) P < 0.05.

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