Domain-selective and sex-dependent regulation of learning and memory in mice by GIRK channel activity in CA1 pyramidal neurons of the dorsal hippocampus
- Haichang Luo1,
- McKinzie Frederick1,
- Ezequiel Marron Fernandez de Velasco,
- Jenna Osterlund Oltmanns,
- Courtney Wright and
- Kevin Wickman
- Corresponding author: wickm002{at}umn.edu
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↵1 These authors contributed equally to this work.
Abstract
G protein-gated inwardly rectifying K+ (GIRK) channels mediate the postsynaptic inhibitory effect of many neurotransmitters in the hippocampus and are implicated in neurological disorders characterized by cognitive deficits. Here, we show that enhancement or suppression of GIRK channel activity in dorsal CA1 pyramidal neurons disrupted novel object recognition in mice, without impacting open field activity or avoidance behavior. Contextual fear learning was also unaffected, but extinction of contextual fear was disrupted by suppression of GIRK channel activity in male mice. Thus, the strength of GIRK channel activity in dorsal CA1 pyramidal neurons regulates select cognitive task performance in mice.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.054022.124.
- Received May 10, 2024.
- Accepted September 15, 2024.
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