Hippocampal motor memory network reorganization depends on familiarity, not time
- D. Gregory Sullens1,
- Phuoc Nguyen1,2,
- Kayla Gilley1,3,
- Madison B. Wiffler4,5 and
- Melanie J. Sekeres1,6
- 1Department of Psychology and Neuroscience, Baylor University, Waco, Texas 76798, USA
- 2Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
- 3Department of Biology and Chemistry, Liberty University, Lynchburg, Virginia 24515, USA
- 4Department of Biology, Baylor University, Waco, Texas 76798, USA
- 5Department of Neurobiology, University of Utah, Salt Lake City, Utah 84112, USA
- 6School of Psychology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
- Corresponding author: msekeres{at}uottawa.ca
Abstract
There is debate as to whether a time-dependent transformation of the episodic-like memory network is observed for nonepisodic tasks, including procedural motor memory. To determine how motor memory networks reorganize with time and practice, mice performed a motor task in a straight alley maze for 1 d (recent), 20 d of continuous training (continuous), or testing 20 d after the original training (remote), and then regional c-Fos expression was assessed. Elevated hippocampal c-Fos accompanied remote, but not continuous, motor task retrieval after 20 d, suggesting that the hippocampus remains engaged for nonhabitual remote motor memory retrieval.
Footnotes
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[Supplemental material is available for this article.]
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.053792.123.
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Freely available online through the Learning & Memory Open Access option.
- Received July 21, 2023.
- Accepted November 6, 2023.
This article, published in Learning & Memory, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
