Reminders reinstate context-specificity to generalized remote memories in rats: relation to activity in the hippocampus and aCC
- Melanie J. Sekeres1,
- Morris Moscovitch2,3,4,
- Cheryl L. Grady2,4,5,
- D. Gregory Sullens1 and
- Gordon Winocur2,4,5,6
- 1Department of Psychology and Neuroscience, Baylor University, Waco, Texas 76798, USA
- 2Rotman Research Institute, Baycrest, Toronto, Ontario M6A 2E1, Canada
- 3Department of Psychology, Baycrest, Toronto, Ontario M6A 2E1, Canada
- 4Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada
- 5Department of Psychiatry, University of Toronto, Toronto, Ontario M5S 3G3, Canada
- 6Department of Psychology, Trent University, Peterborough, Ontario K9J 7B8, Canada
- Corresponding author: melanie_sekeres{at}baylor.edu
Abstract
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a no reminder condition. c-Fos expression in dorsal CA1 was observed following retrieval in the original context, but not in a novel context, whether or not the memory was reactivated, suggesting that dCA1 retains the context-specific representation. c-Fos was highly expressed in aCC following remote memory testing in both contexts, regardless of reminder condition, indicating that aCC develops generalized representations that are insensitive to memory reactivation.
Footnotes
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[Supplemental material is available for this article.]
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.050161.119.
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Freely available online through the Learning & Memory Open Access option.
- Received June 17, 2020.
- Accepted October 15, 2019.
This article, published in Learning & Memory, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
