The amygdalo-nigrostriatal network is critical for an optimal temporal performance
- Mouna Es-seddiqi1,2,
- Nicole El Massioui1,2,
- Nathalie Samson1,2,
- Bruce L. Brown3,4 and
- Valérie Doyère1,2
- 1Université Paris-Saclay, Univ Paris-Sud, CNRS, UMR9197, Institut des Neurosciences Paris-Saclay, F 91405, Orsay, France
- 2CNRS, Orsay, F-91405 UMR 9197, Orsay, France
- 3Department of Psychology, Queens College, Flushing, New York 11367, USA
- 4Graduate Center, City University of New York, New York, New York 10016, USA
- Corresponding author: valerie.doyere{at}u-psud.fr
Abstract
The amygdalo-nigrostriatal (ANS) network plays an essential role in enhanced attention to significant events. Interval timing requires attention to temporal cues. We assessed rats having a disconnected ANS network, due to contralateral lesions of the medial central nucleus of the amygdala (CEm) and dopaminergic afferents to the lateral striatum, as compared to controls (sham and ipsilateral lesions of CEm and dopaminergic afferents to LS) in a temporal bisection task. ANS disconnection induced poorer temporal precision and increased response latencies to a short duration. The present results reveal a role of the ANS network in temporal processing.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.041152.115.
- Received November 19, 2015.
- Accepted December 10, 2015.
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