Neuronal nitric-oxide synthase deficiency impairs the long-term memory of olfactory fear learning and increases odor generalization

Nitric oxide activation does not disrupt the habituation and cross-habituation paradigm. The graphs depict the normalized time investigating the odor from the first H1 trial. All mice investigated the E5 odor during three trials (H1 to H3), the similar E6 odor (SC), and the dissimilar 2H odor (DC). (*) Difference between H3 and H1, characterizing habituation to the odor, (^#) difference between SC and DC to H3, suggesting the ability to discriminate the odors from the habituated odor.