Reactivation of odor memories created by sensory preconditioning using a single pair of odorants. (A,B) Pups were exposed to odorants A+B on day 1 (d1), and conditioned to odorant A by pairing with the MP on day 2. On day 3, they were reactivated by exposure to odorant A (A) or B (B) and injected with anisomycin (AN) or saline. All the pups were tested for their responsiveness to odorants A and B on day 4. Post-reactivation administration of AN impairs only the response to the odorant used as the retrieval cue. (C,D) Pups were exposed to odorants A+B on day 1, reexposed to odorant A (C) or B (D) and injected with AN or saline on day 2, before MP-conditioned to odorant A on day 3. On day 4, they were tested for their responsiveness to odorants A and B. Administration of AN suppresses the initial link created between odorants A and B by sensory preconditioning. (***) P < 0.001, (**) P < 0.01.
