Angiotensin II and AT1 receptor in dorsal hippocampus mediates the endogenous updating. All graphs show percentage of freezing time, expressed as mean ± SEM. The experimental design is shown in the top of each panel. (A) ANGII mimics the water-deprivation effects on memory reconsolidation (vehicle n = 8, ANGII n = 10). (B) The antagonist of ANGII losartan reverts the effect of water deprivation on memory reconsolidation (control group/vehicle n = 10, control group/LOS n = 9, control group/PD n = 7, water deprivation/vehicle n = 8, water deprivation/LOS n = 7, water deprivation/PD n = 8). Groups marked with the same letter (e.g., “a”) are statistically equal to each other and different from those marked with different letters (e.g., “a” groups differ from “b” groups), with significance level of P < 0.05.
