The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association
- Jacek Debiec1,2,3,7,8,
- Lorenzo Diaz-Mataix1,7,
- David E.A. Bush1,
- Valérie Doyère1,4,5 and
- Joseph E. LeDoux1,6
- 1W.M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA
- 2Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
- 3Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
- 4Université Paris-Sud, Centre de Neurosciences Paris-Sud, Orsay F-91405, France
- 5Centre National de la Recherche Scientifique, Orsay F-91405, France
- 6The Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
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↵7 These authors equally contributed to this work.
Abstract
In reconsolidation studies, memories are typically retrieved by an exposure to a single conditioned stimulus (CS). We have previously demonstrated that reconsolidation processes are CS-selective, suggesting that memories retrieved by the CS exposure are discrete and reconsolidate separately. Here, using a compound stimulus in which two distinct CSs are concomitantly paired with the same aversive unconditioned stimulus (US), we show in rats that reexposure to one of the components of the compound CS triggers extinction or reconsolidation of the other component. This suggests that the original training conditions play a critical role in memory retrieval and reconsolidation.
Footnotes
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↵8 Corresponding author
E-mail jdebiec{at}umich.edu
- Received April 22, 2013.
- Accepted September 26, 2013.
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