Deletion of PTEN produces deficits in conditioned fear and increases fragile X mental retardation protein

Loss of PTEN is associated with contextual memory deficits after delayed fear memory. (A) Graph shows the mean (±SEM) percent time freezing during the contextual memory test 24 h after training. Graphs show the mean (±SEM) percent freezing during the new context condition (B) and the conditioned stimulus (tone) condition (C). n = 11, 10, and 10 for WT, HT, and KO, respectively. Significant group difference: (*) P < 0.05.