Temporal- and sex-specific changes in proteasome-dependent and independent polyubiquitination in the amygdala during fear memory formation

M1 polyubiquitination targets change in a sex- and time-dependent manner in the amygdala following contextual fear conditioning. (A) Utilizing previously published proteomic data for 1 h after fear conditioning (Musaus et al. 2021) publicly available with PRIDE accession number PXD025483, we compared the total number of significantly altered M1 polyubiquitin targets across the memory consolidation window to establish a temporal pattern by sex. (B) We then separated the significantly changed targets by positive and negative log₂ fold changes to establish a further understanding of the temporal dynamics.