Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder

Comparison of the three therapeutic approaches. (A) Individual exploration preference index. (B) Time of social interaction. (C) Freezing time. Results are presented as means ± SEM. Holm-Šídák post hoc test. n(CONT) = 5, n(EXT) = 5, n(OXT) = 6, n(HFS) = 5. (*) P < 0.05; (***) P < 0.001 versus CONT. (+) P < 0.05; (++) P < 0.01; (+++) P < 0.001 versus EXT. (OPZ) Outside a proximity zone, (CONT) control, (EXT) extinction, (Oxt) oxytocin, (HFS) high-frequency stimulation.