Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder

Effect of high-frequency brain stimulation of the IL cortex on SFC-induced social fear in male mice. (A) Duration of object exploration. (B) Individual exploration preference index. (C) Time of social interaction. (D) Freezing time. Results are presented as means ± SEM. Post hoc Holm-Šídák test. n(SFC−) = 5, n(SFC+) = 5. (***) P < 0.001 versus OPZ exploration, (##) P < 0.01, (###) P < 0.001 versus SFC−. (+) P < 0.05; (++) P < 0.01; (+++) P < 0.001 versus SEE1. (OPZ) Outside a proximity zone, (IPZ) inside a proximity zone, (HFS) high-frequency stimulation.