Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder

Effect of acute oxytocin treatment on SFC-induced social fear in male mice. (A) Duration of object exploration. (B) Individual exploration preference index. (C) Time of social interaction. (D) Freezing time. Results are presented as means ± SEM. Post hoc Holm-Šídák test. n(SFC−/Veh) = 5, n(SFC−/OXT) = 8, n(SFC+/Veh) = 5, n(SFC+/OXT) = 6. (*) P < 0.05; (**) P < 0.01 versus OPZ exploration. (μ) P < 0.05, (μμμ) P < 0.001 versus SFC−/Veh. ($) P < 0.05, ($$) P < 0.01, ($$$) P < 0.001 versus SFC+/Veh. (###) P < 0.001 versus SFC−/OXT. (OPZ) Outside a proximity zone, (IPZ) inside a proximity zone, (Veh) vehicle, (Oxt) oxytocin.