Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation

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Figure 1.
Figure 1.

Global H2Aubi levels decrease in the amygdala following fear conditioning. (A) Experimental design. Rats were trained to contextual fear conditioning, and the BLA was dissected 1 h later. (B) Western blot analysis of H2Aubi levels in BLA bulk histone extractions of young male and female adult rats (n = 10 per group, mixed sex, 8-week-old). H2Aubi levels decreased in the fear-conditioned group relative to the naive animals. Representative images of the H2Aubi on the top and H3 (loading control) on the bottom. (*) P < 0.05 from Naive.

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