Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats

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Figure 5.
Figure 5.

Fear transfer only occurs if exposure to the alternate context happens within the 6 h reconsolidation window. (A) During the reactivation session, freezing levels did not differ between the three groups. Freezing behavior was measured as percent freezing (±SEM) across a 90 sec reactivation session. (B) There were no significant differences in freezing behavior during the post-reactivation sessions. Freezing behavior (n = 8 per group) was measured as percent freezing (±SEM) across the 8 min post-reactivation session. (C) During the test session, the groups exposed to the alternate context immediately (immediate) or 20 min post-reactivation (20 min) froze significantly higher than the group exposed to the alternate context 6 h (6 h) post-reactivation. Freezing behavior (n = 8 per group) was measured as percent freezing (±SEM) across the 8 min test session. (**) P < 0.01.

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