Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

Loss of the H2Bub ligase Rnf20 abolishes the learning-related transcriptome in the hippocampus. Volcano plot of RNA-seq expression data 1 h following training in the dorsal hippocampus with Scr-siRNA (A) and Rnf20-siRNA (B) relative to naive controls from Figure 1. Up-regulated genes are reported in red, down-regulated genes in blue, and not DEGs are represented as black dots. The dotted lines show the thresholds.

This Article

  1. Learn. Mem. 31: