Cover image

In humans, psychological loss can be a precipitating event for the development of clinical depression and anxiety disorders. These losses can be social, such as the death of a loved one or a relationship ending, or nonsocial, like eviction or job loss. Researchers have developed a rodent model for combined social and nonsocial loss and have shown effects on behaviors related to avoidance, stress coping, and cognitive function. In this issue, Gore et al. (LearnMem a053968.124) investigate the differential effects of social and nonsocial environmental loss on ventral hippocampus-dependent behavior and inhibitory synaptic markers. The cover is a confocal image of WFA+/PV+ cells in the ventral CA1 (vCA1) region of the hippocampus. Green channel: Wisteria floribunda agglutinin (WFA); red channel: parvalbumin (PV); blue channel: DNA dye Hoechst 33342.