Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory

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Figure 6.
Figure 6.

Analysis of NOL and NOR memory in inhibitory neuron subclass-specific 4E-BP2 knockout mice. (A) Schematics of the hippocampus-dependent memory tests used for the study. (Left panel) NOL. (Right panel) NOR. (B) DI and total exploration time for Eif4ebp2flx/flx:Pvalb-Cre (n = 12) versus Eif4ebp2+/+:Pvalb-Cre (n = 12) in the NOL task (left panel) and NOR task (right panel). (C) DI and total exploration time for Eif4ebp2flx/flx:Sst-Cre (n = 14) versus Eif4ebp2+/+:Sst-Cre (n = 14) in the NOL task (left panel) and NOR task (right panel). (D) DI and total exploration time for Eif4ebp2flx/flx:Vip-Cre (n = 11) versus Eif4ebp2+/+:Vip-Cre (n = 9) in the NOL task (left panel) and NOR task (right panel). Statistical significance: (*) P < 0.05, (**) P < 0.01, (***) P < 0.001; (ns) not significant, calculated with an unpaired t-test. Data are presented as mean ± SEM. (#) P < 0.05, (##) P < 0.01, (###) P < 0.001; (ns) not significant, calculated by a one-sample t-test. Data are presented with box and whisker plots where “+” indicates the mean. Dashed line indicates no discrimination of objects (i.e., memory impairment).

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  1. Learn. Mem. 31:

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