Elevated corticosterone after fear learning impairs remote auditory memory retrieval and alters brain network connectivity

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Figure 3.
Figure 3.

Corticosterone altered correlated activity between the dentate gyrus, amygdala, and prefrontal cortex subregions. (A) Pearson's correlation matrix of interregional covariance (dorsal dentate gyrus [dDG], ventral dentate gyrus [vDG], lateral amygdala [LA], basal amygdala [BA], prelimbic prefrontal cortex [PL], infralimbic prefrontal cortex [IL], and medial orbitofrontal cortex [mORB]) of the VEH group displays multiple positive correlations of the LA with the BA and the dDG and PFC subregions. (B) The Pearson's correlations matrix of the CORT group displays altered interregional coactivation. (C) Heat map of the Δ Pearson's R (CORT–VEH) compared with a bootstrapped population for significance. Axes represent brain regions, colors reflect Pearson's R-values (scale at the right), and labels within squares correspond to P-values. (*) P < 0.05, (**) P < 0.01, (***) P < 0.001.

This Article

  1. Learn. Mem. 30: 125-132