Effects of NMDARs, mGluRs, group I mGluRs, IP3Rs, CaMKII, or calcineurin activated immediately after LFS on synaptic responses. (A) Summarized results for the time course of changes in the S-EPSP (left panel) or A-PS (right panel) when LFS (1000 pulses at 2 Hz) was delivered to naïve CA1 synaptic inputs and 50 µM AP5 (n = 7, unfilled circles), 100 µM S-4CPG (n = 6, filled circles), or 10 µM 2-APB (n = 6, filled triangles) was applied to the perfusate (gray bar) in the presence of test synaptic inputs during the 20-min period from 0 to 20 min after the end of LFS (black bar). (B) Summarized results for the time course of change in the S-EPSP (left panel) or A-PS (right panel) when LFS (1000 pulses at 2 Hz) was delivered to naïve CA1 synaptic inputs and 10 µM KN-62 (n = 6) or 1 µM FK506 (n = 6) was applied (hatched bar) to the perfusate in the presence of test synaptic input during the 20-min period from 0 to 20 min after the end of LFS (gray bar). In these time course figures, the ordinate shows the S-EPSP or A-PS expressed as a percentage of the averaged value measured during the 10-min period before the delivery of LFS. The symbols and bars represent the mean ± S.E.M.
