Figure 2.
Effect of a CaMKII inhibitor applied for a 10-min period on LTP induction. Summarized time course for the change in the S-EPSP (left panel) or A-PS (right panel) induced by HFS (100 pulses at 100 Hz) when test synaptic stimulation was continued throughout the experiment and the slices were perfused with 10 µM KN-62 for the 10-min period either from 9 min before HFS to 1 min after HFS (n = 6, empty bar and circles (1)) or from 1 to 11 min after HFS (n = 6, filled bar and circles (2)). The horizontal bar marks the period of KN-62 application and the arrow represents the delivery of HFS. The symbols and bars represent the mean ± S.E.M.
