O-GlcNAc and EZH2-mediated epigenetic regulation of gene expression during consolidation of fear memories

Adult hippocampal expression of Ogt and Ezh2 are necessary for hippocampus-dependent memory formation. (A) Schematic of intra-CA1 Ogt siRNA infusion followed by contextual fear conditioning. (B) Performance of male rats in training phase (n = 6, 7; P = 0.1673) and testing phase (n = 6, P = 0.0057) of contextual fear conditioning after Ogt knockdown. (C) Performance of unsynchronized female rats in training phase (n = 7, 9; P = 0.8516) and testing phase (n = 7; P = 0.0610) of contextual fear conditioning after Ogt knockdown.