Figure 1.
Context fear conditioning leads to persistent up-regulation of OGT and O-GlcNAcylation in the hippocampus. (A) Schematic of training paradigm. (B) Quantification and representative images showing increased OGT (n = 5 for all groups; One-way ANOVA with Fisher's exact test, P = 0.0196) and O-GlcNAc (n = 5 for all groups, One-way ANOVA with Fisher's exact test, P = 0.0274) via western blots 1 h after context fear conditioning but not latent inhibition. (C) Quantification and representative images showing increased OGT (n = 4, 5; Student's t-test, P = 0.0468) and O-GlcNAc (n = 5 for all groups; Student's t-test, P = 0.0396) via western blots 24 h after training in context fear conditioning.
