(A) The tracks of rats during place navigation and probe trial. From day 1 to day 3, all groups experienced a gradual learning process. In day 4 of probe trial, siCREB group obviously differed from siScr, LIPO, and wild-type rats, showing less platform crossings and more indistinct tendency toward the platform. (B) Analysis of escape latency in place navigation. All groups of rats exhibited spatial learning. (C–E) Comparison of escape latency in probe trial, of the number of platform crossings and of the time spent in the platform quadrant. Error bars represent SD and significant differences are indicated by (*) P < 0.05, (**) P < 0.01, (***) P < 0.001. N = 10 rats in each group.
