Behavioral and immunohistochemical characterization of rapid reconditioning following extinction of contextual fear

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Figure 5.
Figure 5.

Extinction and rapid reacquisition prior to immunohistochemistry. (A) Overview of the design of Experiment 4. The times listed represent the total time of exposure to the context for a given session. A “+” sign indicates a single 0.75 mA shock and a “−” sign indicates the exposure to the context without shock. (B) The acquisition and extinction curves from Groups REC-EXT and REC-NO EXT as shown by the mean percent freezing for each session; A = acquisition session, E = extinction session (C) Mean percent freezing in the 30 sec pre- and postshock on Day 6 during reconditioning. Rapid reacquisition of freezing relative to initial acquisition occurred in both REC groups, but only in REC-EXT relative to preshock freezing. Significance between groups is represented by (***) P < 0.001; (*) P < 0.05. REC-EXT, n = 6; REC-NO EXT, n = 6; COND, n = 6; HAND, n = 6. Error bars represent standard error of the mean.

This Article

  1. Learn. Mem. 26: 387-402