Figure 4.
The HDAC inhibitor simulates the priming effect of nicotine on cocaine. (A) The injection of SAHA alone did not enhance LTP. (Open squares) control, (closed circles) SAHA. (B) SAHA injection prior to (10 min) the injection of cocaine significantly enhances LTP. (Open squares) cocaine, (closed squares) SAHA+cocaine. (C) The injection of cocaine prior to (10 min) SAHA injection (reverse) did not alter LTP. (Open squares) cocaine, (closed circles) cocaine+SAHA. (D) Histograms show the different changes in LTP in mice treated with SAHA, cocaine, and SAHA+cocaine. (E) Seven-day nicotine, but not 7-d cocaine, significantly increases H3 histone acetylation in the DG.
