The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation

Inhibition of USP14 activity in the amygdala impairs the consolidation of contextual but not auditory fear memories. (A) Pre-training IU1 infusions dose-dependently impaired long-term memory retention for the training context relative to DMSO controls. (B,C) Pre-training IU1 infusions did not impair long-term memory for the auditory CS when tested 1 d (B) and 2 d (C) after the training. (*) P < 0.05.