Attenuation of Golgi cell burst responses by nickel. (A) Responses to the same depolarizing step response before and after bath application of nickel. (B) Nickel (100–200 µM) blocked rebound bursts triggered by hyperpolarizing steps. (C) Burst response triggered by short-duration (50 msec) depolarizing current step. Spiking associated with burst response occurred after current step. Nickel blocked both regenerative depolarizing envelope and spiking associated with burst response. (D) Effect of nickel in a different Golgi cell. While nickel blocked spiking associated with the burst response, nickel did not eliminate regenerative depolarization which was maintained following step offset. Response to 1-sec duration current step in control conditions shown in inset.
