Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning

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Figure 6.
Figure 6.

ADX47273 enhances PP-LFS induced LTD in the CA1 region of the hippocampus. (A) Normalized fEPSP slopes recorded in CA1 from slices from wild-type mice. Interleaved experiments were performed in the presence of vehicle or ADX47273. LTD was significantly enhanced in the presence of the mGluR5 PAM. The PP-LFS protocol consisted of 900 pairs of stimuli (40-msec inter-stimulus interval) delivered at 1 Hz for 15 min. (B) PP-LFS failed to induce LTD in slices taken from mGluR5−/− mice. ADX47273 had no effect on mGluR5−/− slices. PP-LFS protocol consists of 900 pairs of stimuli (40-msec inter-stimulus interval) delivered at 1 Hz for 15 min.

This Article

  1. Learn. Mem. 20: 438-445

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