Figure 2.
Prior administration of ADX47273 did not enhance single-session fear extinction. (Ai–Aiii) Freezing during contextual fear conditioning on Day 1 (Ai); 30-min contextual fear extinction on Day 2 (Aii); and 6 min of LTM test on Day 3 (Aiii). Drug group, n = 12; vehicle group, n = 12. (Bi–Biii) Freezing during tone cued fear extinction. Fear conditioning (three tone–shock pairings) on Day 1 (Bi); tone-cued fear extinction on Day 2 (15 tones of 1 min at 2-min intervals, shown are freezing during tone presentations) (Bii); and tone-cued LTM test on Day 3 (3-min tone after 3 min of acclimation) (Biii). Drug group, n = 8; vehicle group, n = 8.
