Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression

AC 1 TG mice show effective and comparable spatial memory extinction to that of WT animals. (A) Water maze training and extinction protocol. After 6 d of hidden platform training (B), animals were subject to the pool without the platform four times a day for 2 d. The time that animals spent in the target quadrant (C) and the number of crossing over the target platform location (D) were recorded.