Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression

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Figure 1.
Figure 1.

Overexpression of AC1 enhances LTP in vivo without affecting basal transmission and paired-pulse facilitation. (A) WT and AC1 TG mice show comparable basal neural transmission. The slopes of fEPSP stimulated by different stimulation intensities are plotted. (B) WT and AC1 TG mice show similar degree of paired-pulse facilitation, which was examined by comparing the slopes of two fEPSPs triggered by pair stimulation with intervals ranging from 20 to 500 msec. (C) WT and AC1 TG mice show comparable LTP induced by HFS at 100 Hz. (D) HFS at 50 Hz induces significant LTP in AC1 TG but not in WT mice. Representative fEPSPs before (indicated as 1) and 60 min after (indicated as 2) HFS are shown.

This Article

  1. Learn. Mem. 20: 352-357

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