Exogenous application of SKF82958-induced c-Fos immunoreactive nuclei. Three groups of animals were formed based on the top, middle, and bottom third of the distribution of factor scores (reflective of GCAs) obtained from the principal component analysis of learning test performance (high factor scores = better general cognitive performance). Values are expressed as the mean ± SEM. (A) Comparison of the mean number of c-Fos immunoreactive nuclei in the prelimbic cortex of animals that had been characterized as having high, intermediate, or low GCA revealed a significant difference between animals of high GCA and low GCA (P < 0.05). (B) Comparison of the mean number of c-Fos immunoreactive nuclei in the agranular insular cortex of animals characterized for their GCA; no significant differences were observed. (C) No significant difference between groups was observed when the mean number of Fos immunoreactive nuclei in the dorsomedial striatum was compared.
