Number of Fos immunoreactive nuclei from individual animals following an administration of SKF82958. Factor scores for each animal were derived from a principal component analysis of all animals’ performance on five learning tasks. These scores reflect each animal's aggregate performance across all five tasks (higher scores reflect higher GCAs). (A) A significant correlation (P < 0.05) was observed between animals’ factor scores and the average number of Fos immunoreactive nuclei in the prelimbic cortex, indicating that animals with higher GCAs exhibit an increased expression of c-Fos after the administration of SKF82958 relative to animals of lower GCAs. No other comparisons were found to be significant when the number of c-Fos immunoreactive nuclei in the agranular insular cortex (B) or the dorsomedial striatum (C) were compared to the animals’ factor scores.
