Model of the role of PKMζ in memory storage. Local synthesis of PKMζ is inhibited by PIN1. NMDA receptor stimulation relieves this inhibition in an unknown manner. Once PKMζ is synthesized, the kinase is constitutively active. Its activity is further increased by phosphorylation by PDK. PKMζ phosphorylates the GluA2 subunit in AMPA receptors leading to translocation of these receptors into the PSD. Additionally, PKMζ inhibits PIN1 so local translation continues to persistently supply the activated synapse with PKMζ, overcoming protein turnover. Red lines indicate phosphorylations and dashed arrows illustrate translocation of the protein. The model is according to Sacktor (2011).
