Model of the role of PI3K signaling in memory consolidation. At the postsynapse BDNF activates the trkB receptor, resulting in the activation of PI3K. PI3K activates PDK, which in turn activates mTORC1 to regulate local translation of dendritic mRNA. PDK also activates SGK1 to activate IKKα, which phosphorylates histone 3 in the nucleus to facilitate gene transcription that contributes to memory consolidation. Additionally, NMDA receptor activation leads to p25 formation by calpain-mediated cleavage of p35. Cdk5 phosphorylates trkB and this phosphorylation is essential for Rac1 and PAK activation to induce actin remodeling. Red arrows indicate phosphorylations and dashed arrows illustrate translocation of the protein.
