SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons

SGK up-regulates PSD-95 expression in the hippocampus. (A) Representative gel pattern showing PSD-95 and β-actin protein bands after PEI, pcDNA3 plasmid, and SGKS422D transfection to the CA1 area. (B) Statistical analyses revealed that SGKS422D transfection significantly increased the PSD-95 level in the hippocampus (**P < 0.01 when compared with the pcDNA3 group). pcDNA3 plasmid transfection alone did not have an effect on PSD-95 expression (P > 0.05). N = 5 each group. Data are mean ±SEM.