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Published online before print November 13, 2006, 10.1101/lm.316006
LEARNING & MEMORY 13:801-808
©2006 by Cold Spring Harbor Laboratory Press; ISSN 1072-0502/06 $5.00
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Research
Development switch in neural circuitry underlying odor-malaise learning

Kiseko Shionoya, Stephanie Moriceau, Lauren Lunday, Cathrine Miner, Tania L. Roth1, and Regina M. Sullivan2

Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019, USA

Fetal and infant rats can learn to avoid odors paired with illness before development of brain areas supporting this learning in adults, suggesting an alternate learning circuit. Here we begin to document the transition from the infant to adult neural circuit underlying odor-malaise avoidance learning using LiCl (0.3 M; 1% of body weight, ip) and a 30-min peppermint-odor exposure. Conditioning groups included: Paired odor-LiCl, Paired odor-LiCl-Nursing, LiCl, and odor-saline. Results showed that Paired LiCl-odor conditioning induced a learned odor aversion in postnatal day (PN) 7, 12, and 23 pups. Odor-LiCl Paired Nursing induced a learned odor preference in PN7 and PN12 pups but blocked learning in PN23 pups. 14C 2-deoxyglucose (2-DG) autoradiography indicated enhanced olfactory bulb activity in PN7 and PN12 pups with odor preference and avoidance learning. The odor aversion in weanling aged (PN23) pups resulted in enhanced amygdala activity in Paired odor-LiCl pups, but not if they were nursing. Thus, the neural circuit supporting malaise-induced aversions changes over development, indicating that similar infant and adult-learned behaviors may have distinct neural circuits.

Received May 10, 2006; accepted in revised form July 21, 2006.

1 Present address: Department of Neurobiology, University of Alabama–Birmingham, Birmingham, AL 35294, USA.

2 Corresponding author.

E-mail rsullivan{at}ou.edu; fax (405) 325-2699.

Article published online before print. Article and publication data are at http://www.learnmem.org/cgi/doi/10.1101/lm.316006


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[Abstract] [Full Text] [PDF]


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